Promoted Sunderland, who have defied expectations to stay in the top half of the Premier League table, could be the worst affected with six players going to the tournament, while the likes of Fulham, Manchester United, Burnley and Crystal Palace will also have to make do without some key personnel.
Manchester City's Erling Haaland became the fastest player to reach 100 Premier League goals to ignite their charge on Tuesday.
Bournemouth's Antoine Semenyo scored inside the first minute as they ended a run of eight games without a victory thanks to a 1-0 Premier League home win over Fulham on Monday, a result that reignites their hopes of European football next season.
Images from Thursday's action in the Premier League.
Fulham held visitors Manchester United to a 1-1 draw in the Premier League on Sunday.
Cristiano Ronaldo came off the bench to earn Manchester United a hard-fought 2-1 victory at Everton in the Premier League on Sunday, taking his career goal tally to 700 in the process.
IMAGES from the Premier League matches played on Sunday.
IMAGES from the Premier League matches played on Tuesday.
A round-up of Saturday's action in the Premier League.
Liverpool moved one win away from sealing the Premier League title as substitute Trent Alexander-Arnold secured a 1-0 victory at Leicester City
A summary of Saturday's action in the English Premier League.
A summary of Saturday's action in the Premier League.
Manchester City and Arsenal closed in on Premier League leaders Liverpool with contrasting victories on Saturday as Manchester United's bubble was burst by Fulham.
Marcus Rashford and Joshua Zirkzee bagged two goals apiece as Manchester United thumped Everton 4-0 on Sunday in new manager Ruben Amorim's first Premier League match at Old Trafford.
Aston Villa claimed their first three points of the Premier League Season
Images from the English Premier League matches played on Sunday night.
IMAGES from the Premier League matches played on Saturday
Images from the English Premier League matches played on Sunday
In an Instagram post by Esha, Iwobi was called 'gorilla'.
All the action from soccer matches played in Europe on Monday.
IMAGES from the Europa League matches played on Thursday
First-half goals by Danny Welbeck and Alex Iwobi earned Arsenal a first win in four league games to revive their Premier League title hopes in the early kickoff at Goodison Park on Saturday.
IMAGES from the Premier League matches played on Saturday.
Riyad Mahrez, who inspired Leicester City to an extraordinary Premier League title triumph last season, was named African Footballer of the Year on Thursday.
Norwich opened the floodgates in one of three earlier kickoffs, with their new U.S. international signing Josh Sargent and Greek winger Christos Tzolis each scoring twice on their full debuts at Carrow Road.
IMAGES from Premier League matches played on Saturday.
A Sergio Aguero hat-trick helped Manchester City get back to winning ways in the Premier League with a 3-1 victory over Newcastle United, as they stayed 12 points ahead of Manchester United who had to dig deep to secure a 1-0 win at Burnley.
Ahmed Musa returned to the line-up with devastating effect as he scored both goals for Nigeria to help them resuscitate their World Cup hopes in a 2-0 win over Iceland at the Volgograd Arena on Friday.
Arsenal shoved Chelsea off the top of the table but Leicester City's Jamie Vardy, with a dazzling hat-trick, was the man of the moment on Saturday as the struggling Premier League champions blew aside Manchester City 4-2.
Images from the Premier League matches played on Saturday, March 9.
Manchester City suffered their first home Premier League loss in eight months as a shock 3-2 defeat by Crystal Palace on Saturday left Pep Guardiola's champions trailing leaders Liverpool by four points.
A summary of Sunday's action in the Premier League.
There was eye-catching sports action the world over and we summarise it all in this breathtaking photo feature...
Manchester United moved three points clear at the top of the Premier League after a Paul Pogba goal gave them a hard-fought 1-0 win over Burnley at a freezing Turf Moor on Tuesday.
Olivier Giroud scored the decisive spot kick as Arsenal beat Chelsea 4-1 in a penalty shootout to win the Community Shield at Wembley on Sunday.
Manchester United kept up the positive momentum of their pre-season tour with a 3-1 victory over Barcelona in the International Champions Cup on Saturday in Santa Clara, California.
Images from the English Premier League matches played on Sunday.
With United unable to sign a replacement, the pressure will be on 21-year-old England forward Marcus Rashford to deliver the goals in a more central role than he has previously operated in.
The Merseyside club have suffered defeats in three of their past four Premier League matches
IMAGES from the English Premier League matches played on Sunday